The International Conference on the Challenges faced by Technical and Scientific Support Organizations (TSO) in Enhancing Nuclear Safety and Security: Enhancing science and adaptability in a changing world and creating perspective for a young generation to be held in Saint Petersburg, Russian Federation, from 10-13 October 2022 will continue the tradition established by the four preceding conferences on this subject, which were held, respectively in Brussels, Belgium (2018), Beijing, China (2014), in Tokyo, Japan (2010) and in Aix-en-Provence, France (2007).